Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder
Rhonda Patrick explains how intestinal permeability allows lipopolysaccharide (LPS) to enter circulation, driving systemic inflammation, atherosclerosis via small dense LDL, and blood-brain barrier breakdown linked to desummaryStress-Gut Axis: Psychological stress releases corticotropin-releasing hormone, which binds to mast cells in the gut. This triggers the release of proteases that degrade tight junction proteins, directly causing intestintakeawayShe identifies stress, obesogenic diets, and specific fat types as key drivers of gut permeability, while highlighting omega-3s, butyrate-producing fibers, and exercise as protective factors.summary
