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Chapters & Sections (164)
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00:00
Insulin Resistance, Depression Risk, and Paradigm Shifts
00:30
What Is Metabolic Psychiatry? Overview of Systemic and Central Dysfunction
01:00
Podcast Host Introduction and Guest Welcome
01:32
Revisiting Early Work on Body-Mind Connection
02:02
Body Mind Effect and Physiological Impact on Brain Health
02:34
Origins of Metabolic Psychiatry and Early Literature
03:05
Historical Biomarkers: Lactate, Glutathione, and Bioenergetic Dysfunction
03:35
Metabolic Dysregulation in Serious Mental Illnesses
04:07
Defining Metabolism and Its Role in Energy Production
04:37
Holistic View of Metabolic Psychiatry: Central and Systemic Dysfunction
05:08
Clarifying Misconceptions About Ketogenic Diet and Brain Energy
05:40
Comprehensive Metabolic Pathways and Their Impact on Mental Health
06:12
Medical Education Gaps in Nutrition, Insulin Resistance, and Metabolism
06:43
Integrating Nutritional Science into Metabolic Psychiatry Practice
07:13
Stigma and Misconceptions About Mental Illness
07:43
Historical Perspectives on Mental Health Diagnosis
08:15
Metabolic Psychiatry as a New Paradigm
08:46
Interdisciplinary Roots of Metabolic Psychiatry
09:17
Challenges in Treating Severe Psychiatric Illnesses
09:50
Early Exposure to Nutrition During Medical Training
10:20
Clinical Observation of Metabolic Issues in Psychiatric Patients
10:52
Transition to Obesity Medicine and Psychiatry
11:24
Neuro‑Metabolic Therapies for Seizures and Psychiatric Conditions
11:56
Research Trials on Metabolism‑Based Interventions
12:29
Primary Care Observations of Diabetes and Depression
12:59
Epidemiology of Metabolic Dysfunction in Psychiatric Populations
13:31
Public Health Data on Insulin Resistance and Mental Health Risk
14:02
Societal Impact of Poor Diet on Brain and Body
14:33
Vicious Cycle Between Depression and Metabolic Health
15:04
Cerebral Hypometabolism in Schizophrenia and Bipolar Disorder
15:35
Early Insulin Resistance Before Psychosis Diagnosis
16:09
Medication Effects on Central Insulin Signaling
16:42
Peripheral Insulin Resistance and Appetite Regulation
17:13
Lithium’s Dual Role in Insulin Signaling
17:44
Peripheral Insulin Resistance and Hippocampal Atrophy
18:16
Metabolic Dysregulation Leading to Psychiatric Symptoms
18:48
Brain Structural Changes from Peripheral Insulin Resistance
19:18
Mitochondrial Dysfunction in Type 2 Diabetes
19:50
Inflammation and Oxidative Stress as Vicious Cycles
20:21
Dietary Interventions to Reset Brain Energy Systems
20:51
Metabolic Pathways Targeted by Pharmacology and Nutrition
21:22
Inflammation Markers in Diabetes and Neuropsychiatric Illnesses
21:53
Limitations of Anti-Inflammatory Therapies for Depression
22:24
Metformin’s Neuroprotective and Metabolic Effects
22:54
TNF‑α and Cytokine Reduction by Metformin
23:26
Metformin Enhancing Psychiatric Medication Efficacy
23:58
Lifestyle Factors Driving Blood Sugar Dysregulation
24:28
Metabolic Psychiatry Tools Beyond Medication
24:58
Exercise, BDNF, and Cognitive Benefits
25:29
Mitochondrial Dysfunction Across Neuropsychiatric Conditions
26:02
Co‑actors and Nutrient Supplementation for Energy Production
26:32
Assessing Deficiencies in Metabolic Psychiatry Clinics
27:33
Omega‑3 Supplementation and Early Psychosis Outcomes
28:04
Preventive Focus on Insulin Resistance and Depression
28:35
Holistic Nutrient Optimization for Mitochondrial Function
29:37
Biomarkers Beyond Lipids and Glucose in Mental Illness
30:39
Randomized Control Trial Funding and Focus
31:09
Ketogenic Diet as Metabolic Intervention
31:41
Triglyceride/HDL Ratio and Insulin Resistance
32:13
Biomarker Nuances in Depression Severity
32:44
Comprehensive Nutrient and Hormone Panel
33:15
Functional Health Blood Tests for Metabolic Dysfunction
33:46
Prevalence of Nutritional Deficiencies in Population
34:18
Paradigm Shift to Network-Based Treatment
34:48
Gluten Antibodies and Brain Inflammation
35:18
Mitochondrial Evaluation in Clinical Practice
35:49
Brain Energy Demands and Vulnerability
36:20
Regional Brain Metabolic Differences
36:53
Collaborative Mitochondrial Research Initiatives
37:23
Omics and Wearable Data Integration
37:53
Ketone Metabolite Biomarkers for Appetite Regulation
38:25
Laboratory Tests for Mitochondrial Health
38:55
Cheek Swab Respiratory Chain Analysis
39:30
Epigenetic and Metabolic Monitoring in the Trial
40:00
Support Structures for Patients with Mental Illness
40:30
Lifestyle Change Implementation and Support Groups
41:00
Clinical Outcomes from the Ketogenic Diet Trial
42:02
Patient Motivation and Long-Term Adherence
43:06
Scaling the Approach Beyond Academic Settings
44:09
Industry Collaboration and Commercialization Efforts
45:10
Navigating Institutional Support and Skepticism
45:42
Defining Metabolic Psychiatry
46:13
Evidence and Future Directions
46:45
Funding Opportunities for Nutritional Science
47:16
Personal Injury and Insight into Pain Management
47:47
Advocacy Manual Development
48:49
Metabolic Approach Across Mental Health Spectrum
49:20
Heimman Hive Community Features
49:51
Early Clinical Observations on Autoimmune and Metabolic Conditions
50:23
Book Development Motivated by Patient Outcomes
50:53
Systemic Treatment Approach and Patient Success Stories
51:56
Data Collection Strategy and Collaboration with Stanford
52:58
Biomarker Scale and Funding Challenges
53:28
Institutional Support and Open-Mindedness
53:58
Integrating Psychedelic Medicine with Metabolic Psychiatry
54:28
Biological and Psychological Interplay in Trauma
54:59
Ketogenic Diets for Eating Disorders
55:30
Neurochemical Pathways in Anorexia and Bulimia
56:02
Ketogenic Diet Impact on Binge Eating and Food Addiction
56:33
Case Series on Food Addiction Improvement
57:04
Challenges of Implementing Ketogenic Diets
57:35
Obesity Drug Trial in Binge Eating and Bulimia
58:06
Critique of DSM-5 and Need for Biomarkers
58:37
Metabolic Pathways as Predictive Biomarkers
59:08
Personalized Treatment Based on Metabolic Data
1:00:09
Combining Metabolic Psychiatry with Precision Medicine
1:00:41
Personalized Functional Assessments
1:01:12
Microbiome and Mitochondrial Focus
1:01:42
Root Cause Medicine Vision
1:02:44
Digital Care Access and Scalability
1:03:14
Therapeutic Toolbox Overview
1:03:45
Microbiome‑Based Psychiatric Interventions
1:04:16
Case Study: Pediatric Behavioral Crisis
1:04:46
Microbiome Reset Success Story
1:05:17
PANS and Biomarker Insights
1:06:18
Metabolic Psychiatry Diagnostic Suite
1:06:51
Omics and AI‑Driven Personalization
1:07:21
Future of Digital Mental Health Care
1:07:51
Website Overview and Free Resources
1:08:22
Virtual Remote Care Platform
1:08:54
Research Article and Future Work
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