Loading transcript...
Click for full transcript
Chapters & Sections (135)
▼
00:00
Cellular Basis of Death
00:30
Host and Guest Introduction
01:31
Topic Framing: Why We Die?
02:32
Veni Rama Krishnan Biography
03:38
Awards and Honors Overview
04:08
Life Definition by Biologists
05:10
Individual Death and Cellular Paradox
06:13
Societal vs Individual Death Distinctions
07:46
Brain Death and Organ Donation
08:17
End‑of‑Life Physiological Considerations
08:49
Case of California vs. New Jersey Death Laws
09:19
Discussion on Brain Death Definition
09:50
Birth and Death as Fuzzy Concepts
10:21
Aging Begins at Conception
10:54
Cellular and Molecular Accumulation of Damage
11:24
Distinguishing Cells, Proteins, and Aging
11:58
DNA Damage and Epigenetic Modifications
12:29
Epigenetics vs. Gene Editing
13:32
Protein Function and Aging-Related Aggregation
14:04
Mitochondrial Evolution and Free Radical Damage
16:08
Mitochondrial DNA Replication Errors
16:38
Cascade Failure of Aging and Mitochondrial Health
17:11
Cyanobacteria and Atmospheric Oxygen
17:42
Timeline of Earth's Oxygenation
18:13
Definition and Role of Senescent Cells
18:45
DNA Damage Response and Cell Fate Decisions
19:47
Inflammatory Signaling by Senescent Cells
20:18
Cytokine Storm and COVID-19 Mortality
20:49
Historical Milestones in Reprogramming
21:21
Cloning Experiments and Epigenetic Resetting
22:24
Yamanaka Factors and Induced Pluripotent Stem Cells
23:58
Nobel Recognition and Scientific Impact
24:29
Translational Potential in Regenerative Medicine
24:59
Applications to Tissue Repair and Disease Models
25:30
Comparative Regeneration in Non-Human Species
26:00
Genetic Parity Between Humans and Simple Organisms
26:30
Stem Cell Decline with Age
27:01
Experimental Regeneration in Mice
27:33
Safety and Cancer Risk Concerns
28:03
Rejuvenation vs. Cloning Debate
29:05
Philosophical Questions of Identity and Continuity
29:55
Human Longevity Compared to Other Mammals
30:06
Evolutionary Trade-offs in Lifespan
31:11
Resource Allocation Between Growth and Maintenance
32:14
Examples of Long-lived Vertebrates
33:53
Biological Immortality in Hydra and Jellyfish
34:20
Methuselah Reference and Evolutionary Lifespan
34:51
Evolutionary Selection for Early Life Fitness
35:22
Aging as a Byproduct of Reproductive Success
35:54
Human Longevity Compared to Mammals
36:26
Bat Longevity and Flight Advantages
36:57
Aging Interventions Introduction
37:28
Young Blood Transfusion Methodology
37:59
Effects of Old vs. Young Blood on Rodents
38:30
Commercialization and FDA Response
39:01
Stem Cell Reprogramming Overview
39:31
Caloric Restriction Experiments in Model Organisms
40:03
Biochemical Pathways of Caloric Restriction
41:04
Intermittent Fasting and Mimetic Strategies
42:06
Rapamycin Discovery and Origin
42:37
Discovery of Rapamycin’s Immunosuppressive Properties
43:07
Rapamycin’s Role in Caloric Restriction and Aging Studies
43:39
Discussion of Time Dilation for Space Travelers
44:09
Scott Kelly Twin Experiment and Biological Age Difference
45:11
Entropy in Living Systems and Energy Input from the Sun
45:42
Maintenance, Repair, and Decay of Biological Systems
46:13
Variability of Organ Aging Within an Individual
46:44
ATP Production and Energy Losses in Cellular Processes
47:15
Implications of the Second Law for Biological Aging
48:18
Ethical Considerations in Anti-Aging Research
50:50
Record-Breaking Longevity Stories
51:21
Public Reactions to Extreme Ages
51:53
Biological Limits and Species Comparisons
52:23
Skepticism About Unlimited Life Extension
52:57
AI’s Role in Protein Folding and Aging Research
53:28
Colonization Possibilities vs. Immediate Earth Needs
54:00
Demographic Shifts from Extended Lifespan
54:31
Creative Energy and Age Dynamics
55:02
Retirement Perspectives of Long-Lived Individuals
55:33
Population Pyramid Inversion and Power Accumulation
56:04
Political Implications of Aging Leadership
56:36
Individual Willingness for Extended Healthy Life
57:07
Philosophical Reflections on Death and Motivation
57:38
The Value of Finite Life in Driving Achievement
58:08
Humorous Take on Longevity Aspirations
58:39
Health Span vs Lifespan Debate
59:10
Poetic Illustration of Aging
59:41
Potential for Extended Lifespan
1:00:12
Population Growth Concerns with Immortality
1:00:44
Demographic Trends in Korea
1:01:17
Value of Knowing One's Mortality
1:01:52
Mathematical Perspective on Death and Meaning
1:02:24
Contemplating a Life-Extending Pill at Deathbed
1:02:55
Final Sign-Off and Credits
1h 45m⏭ 1
1h 14m⏭ 1
26m
1h 0m⏭ 1
1h 17m
53m
1h 43m⏭ 1
56m
1h 6m
1h 7m
49m
48m
48m⏭ 1
1h 40m⏭ 3
1h 20m
1h 22m
1h 16m⏭ 4
1h 50m⏭ 3
1h 0m⏭ 1
31m⏭ 1
4h 6m⏭ 2
2h 15m⏭ 2
1h 1m
1h 28m⏭ 2